Gypensapogenin H, a novel dammarane-type triterpene induces cell cycle arrest and apoptosis on prostate cancer cells
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- 作者：Xiao-Shu Zhanga ; b ; Chen Zhaob ; c ; Wei-zhuo Tanga ; b ; Xiao-jun Wua ; b ; Yu-Qing Zhaoa ; b ; zyq4885@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Novel triterpenes ; Anti-tumor activity ; Apoptosis ; Gynostemma pentaphyllum
- 刊名：Steroids
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：104
- 期：Complete
- 页码：276-283
- 全文大小：1851 K
文摘
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The novel dammarane-type triterpene inhibited the growth of human prostate cancer cells.
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GH exhibited the strongest inhibitory effects on DU145 and 22RV-1 cells.
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It significantly inhibited proliferation and decreased survival.
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For the both cell lines, GH led to cell cycle arrest and induced apoptosis.