Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia

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• 作者：Gao-Ting Zhao^a ; Jie-Qing Liu^b ; Yuan-Yuan Deng^b ; ^c ; Hai-Zhou Li^a ; Jian-Chao Chen^b ; Zhi-Run Zhang^b ; Lin Zhou^b ; Ming-Hua Qiu^b ; ^c ; ^{mhchiu@mail.kib.ac.cn" class="auth_mail}
• 关键词：Momordica charantia ; Cucurbitaceae ; Cucurbitane-type triterpenoids ; Cytotoxicity
• 刊名：Fitoterapia
• 出版年：June 2014
• 年：2014
• 卷：95
• 期：Complete
• 页码：75-82
• 全文大小：377 K

文摘

Six new cucurbitane-type triterpenoids, karavilagenin F (1), karavilosides XII and XIII (2, 3), momordicines VI, VII, and VIII (4, 5 and 6), along with four known ones, 5尾,19-epoxy-25-methoxycucurbita-6,23-diene-3尾,19-diol (7), 5尾,19-epoxycucurbita-6, 23-diene-3尾,19,25-triol (8), kuguacin R (9), and (19R,23E)-5尾,19-epoxy-19-methoxycucurbita-6,23,25-trien-3尾-ol (10), were isolated from the stems and leaves of Momordica charantia L. Their chemical structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, COSY, and ROESY), MS experiments, and CD spectrum. Compound 6 showed weak cytotoxicity against five human cancer cells lines with IC₅₀ values of 14.3–20.5 渭mol/L.