Fat/fiber intakes and sex hormones in healthy premenopausal women in USA

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• 作者：Mylè ; ne Aubertin-Leheudre ; Sherwood Gorbach ; Margo Woods ; Johanna T. Dwyer ; Barry Goldin ; Herman Adlercreutz
• 关键词：Diet ; Estrogens ; Breast cancer risk ; Women
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2008
• 出版时间：November 2008
• 年：2008
• 卷：112
• 期：1-3
• 页码：32-39
• 全文大小：212 K

文摘

The mechanisms by which diet affects breast cancer (BC) risk are poorly understood but a positive relationship between fat and a negative association with fiber intake and BC risk have been demonstrated. Here we study the association between dietary fat/fiber ratio and estrogen metabolism. Fifty women were recruited, 22 were included in the low fat/high fiber and 22 were in the high fat/low fiber group and 6 did not meet our criteria. Estrogens (determined in plasma, urine and feces) and dietary records were collected during 3 following days. All data were collected in winter and in summer. The high fat/low fiber group had significantly higher urinary total estrogens, estriol-3-glucuronide, 2-hydroxyestradiol, 16α-hydroxyestrone, and a higher 2-hydroxyestrone/4-hydroxyestrone ratio. Total fat intake correlated significantly with plasma estrone, estradiol, urinary 2-hydroxyestrone, 2-hydroxyestradiol, 2-hydroxyestrone/4-hydroxyestrone ratio, and total urinary estrogens, even after adjustment for total fiber intake. The high fat/low fiber diet was associated with high values both for catechol and 16α-hydroxylated estrogens and a high 2-hydroxyestrone/4-hydroxyestrone ratio, but 2-hydroxyestrone/16α-hydroxyestrone ratio was not different between the groups. Our results suggest that fat affects estrogen metabolism more than does fiber and that one mechanism resulting in high estrogen values is an increased reabsorption of biliary estrogens.