miR-22 regulates cell invasion, migration and proliferation in vitro through inhibiting CD147 expression in tongue squamous cell carcinoma
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- 作者：Kaifeng Qiua ; b ; c ; 1 ; Zixian Huanga ; d ; 1 ; Zhiquan Huanga ; d ; zhiquanhuang1978@126.com" class="auth_mail" title="E-mail the corresponding author ; Zhichao Heb ; Siping Youb
- 关键词：HNSCC ; head and neck squamous cell carcinoma ; TSCC ; tongue squamous cell carcinoma ; EMMPRIN ; extracellular matrix metalloproteinase inducer ; miRNA ; microRNA ; MMP ; matrix metalloproteinases ; CCK-8 ; cell counting kit-8 ; PBS ; phosphate buffered saline
- 刊名：Archives of Oral Biology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：66
- 期：Complete
- 页码：92-97
- 全文大小：1491 K
文摘
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We applied cotransfection with miR-22 and CD147 in researching their roles in tongue squamous cell carcinoma (TSCC).
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The down-regulation of miR-22 results in the up-regulation of CD147.
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We demonstrate that CD147 is a downstream factors of miR-22.
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The interaction of miR-22 and CD147 may act as a novel therapeutic targets for the treatment of TSCC.