A C. elegans Thermosensory Circuit Regulates Longevity through crh-1/CREB-Dependent flp-6 Neuropeptide Signaling
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- 作者：Yen-Chih Chen1 ; 2 ; 3 ; Hung-Jhen Chen1 ; 2 ; 4 ; Wei-Chin Tseng1 ; 5 ; Jiun-Min Hsu1 ; 6 ; Tzu-Ting Huang1 ; Chun-Hao Chen1 ; Chun-Liang Pan1 ; 7 ; chunliangpan@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：24 October 2016
- 年：2016
- 卷：39
- 期：2
- 页码：209-223
- 全文大小：3946 K
文摘
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crh-1 and flp-6 are necessary and sufficient for longevity response to temperature
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flp-6 is a transcriptional target of crh-1 in the thermosensory neurons
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CRH-1 and FLP-6 act through the AIY interneuron for longevity control
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crh-1 and flp-6 inhibit intestinal ins-7 to promote longevity