Interaction behaviour of trimesoyl chloride derived 1st tier dendrimers determined with structural and physicochemical properties required for drug designing

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• 作者：Sachin B. Undre^a ; ^{mansingh50@hotmail.com} ; Man Singh^a ; ^{sachincug@gmail.com} ; R.K. Kale^a ; ^b ; ^{raosahebkale@gmail.com}
• 关键词：Dendrimer ; Interacting capacity ; Intermolecular interaction ; Activation energy ; Thermal behaviour ; Alkyl chain activity
• 刊名：Journal of Molecular Liquids
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：182
• 期：Complete
• 页码：106-120
• 全文大小：2133 K

文摘

Trimesoyl 1, 3, 5-tridimethyl malonate (TTDMM) and trimesoyl 1, 3, 5-tridiethyl malonate (TTDEM) dendrimers synthesised from trimesoyl chloride (TMC) with dialkyl malonate ester (DME) in 1:3 mass ratio in alcoholic medium are reported. TTDMM and TTDEM as white solids with ¡Ö 95 % yield have shown 144.22 ¡ãC and 131.78 ¡ãC MP respectively. FTIR and 500 MHz ¹H NMR have determined structures and thermal stability was studied with DSC. Their densities (¦Ñ ¡À 10³ kg m^? 3), viscosities (¦Ç ¡À 10^? 4 mPa¡¤s), surface tension (¦Ã ¡À 0.01 mN m^? 1) and activation energies ( ¡À 10^? 2 kJ/mol) for 2.0 to 8.0 mM/L were determined with DMSO at 298.15 K. Activation energies were calculated from viscosities. Data were regressed for limiting densities, viscosities, surface tension and activation energies for dendrimer-DMSO interaction activities. Negative limiting activation energy values ( < 0) as TTDMM > TTDEM inferred comparatively higher energy utilization with ethyl group. Higher limiting density and viscosity for TTDEM have depicted stronger TTDEM-DMSO interaction due to higher entanglement with stronger structural activities as compared to TTDMM. This paper focuses on the role of CH₂ of dialkyl malonate ester on their structural and physicochemical properties for using these dendrimers as drug vehicles.