EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells

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• 作者：Florian Wanke¹ ; Sonja Moos¹ ; Andrew L. Croxford¹ ; André ; P. Heinen¹ ; Stephanie Grä ; f¹ ; Bettina Kalt¹ ; Denise Tischner² ; Juan Zhang³ ; Isabelle Christen³ ; Julia Bruttger¹ ; Nir Yogev¹ ; Yilang Tang¹ ; Morad Zayoud¹ ; Nicole Israel¹ ; Khalad Karram¹ ; Sonja Reiß ; ig¹ ; Sonja M. Lacher¹ ; Christian Reichhold¹ ; Ilgiz A. Mufazalov¹ ; Avraham Ben-Nun⁴ ; Tanja Kuhlmann⁵ ; Nina Wettschureck² ; Andreas W. Sailer⁶ ; Klaus Rajewsky⁷ ; Stefano Casola⁸ ; ^{stefano.casola@ifom.eu} ; Ari Waisman¹ ; ^{waisman@uni-mainz.de} ; Florian C. Kurschus¹ ; ⁹ ; ^{kurschus@uni-mainz.de}
• 关键词：EBI2 ; GPR183 ; 7α ; 25-OHC ; oxysterol ; CH25H ; Th17 ; EAE ; CNS ; multiple sclerosis ; microglia
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：31 January 2017
• 年：2017
• 卷：18
• 期：5
• 页码：1270-1284
• 全文大小：5410 K
• 卷排序：18

文摘

EBI2 in T cells is highly regulated and stabilized in Th17 cells by IL-1β and IL-23 CH25H, CYP7B1, and 7α,25-OHC are elevated in the CNS in EAE EBI2 expression by Th17 cells promotes passive EAE Infiltrating cells in MS lesions express EBI2