Hybrids of thienopyrimidinones and thiouracils as anti-tubercular agents: SAR and docking studies

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• 作者：Mahesh M. Pisal^a ; Laxman U. Nawale^b ; Manoj D. Patil^a ; Sujit G. Bhansali^b ; Jayant M. Gajbhiye^a ; Dhiman Sarkar^b ; Subhash P. Chavan^a ; Hanumant B. Borate^a ; ^{hb.borate@ncl.res.in}
• 关键词：Tuberculosis ; Antitubercular activity ; Thienopyrimidinone ; Thiouracil ; Docking
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：459-469
• 全文大小：1474 K
• 卷排序：127

文摘

New hybrids of thienopyrimidinones and thiouracils synthesized. Some of the compounds exhibited significant antitubercular activity against MTB H37Ra. The docking study done to predict the probable mode of action. Inhibition of mycobacterial pantothenate synthetase predicted.