Design and synthesis of 5-methylpyrazine-2-carbohydrazide derivatives: A new anti-tubercular scaffold

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• 作者：P.B. Miniyar^a ; ^{pankajmpharm@yahoo.co.in} ; ^{pankajmpharm@rediffmail.com} ; S.N. Mokale^b ; S.J. Makhija^c
• 关键词：Anti-tubercular ; 2D QSAR ; 5-Methylpyrazine-2-carbohydrazide ; Mycobacterium tuberculosis
• 刊名：Arabian Journal of Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：10
• 期：1
• 页码：41-46
• 全文大小：760 K
• 卷排序：10

文摘

A simple synthetic methodology was employed for synthesis of series of 5-methylpyrazine-2-carbohydrazide derivatives (PM series). In vitro anti-tubercular activity was evaluated against Mycobacterium tuberculosis (H37Rv) in Middle brook 7H-9 broth medium. Amongst synthesized compounds, seven compounds showed remarkable anti-tubercular activity. The 2-D QSAR illustrates the design PM series of compounds as potential anti-tubercular scaffolds that can be further optimized to improve the activity.