Artesunate induces ROS-dependent apoptosis via a Bax-mediated intrinsic pathway in Huh-7 and Hep3B cells
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- 作者：Yilin Panga ; Guiqi Qina ; Liping Wua ; Xiaoping Wangb ; txp2938@jnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Tongsheng Chena ; chentsh@scnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; chentsh126@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ARS ; artesunate ; ART ; artemisinin ; ARTs ; ART compounds ; BSO ; l-buthionine-sulfoximine ; CCK-8 ; Cell Counting Kit-8 ; Cyt.c ; cytochrome c ; DCF-DA ; 2&prime ; 7&prime ; -dichlorodihydrofluorescein diacetate ; DHA ; dihydroartemisinin ; FITC ; fluorescein isothiocyanate ; FCM ; flow cytometry ; GSH ; reduced glutathione ; HCC ; hepatocellular carcinoma ; MOMP ; mitochondrial outer membrane permeabilization ; NAC ; N-acetyl-cysteine ; PFT ; Pifithrin-alpha ; PS ; phosphatidylserine ; Rho123 ; Rhodamine123 ; ROS ; reactive oxyg
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：347
- 期：2
- 页码：251-260
- 全文大小：2498 K
文摘
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ARS induces ROS-dependent apoptosis in Huh-7 cells and Hep3B cells.
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ARS increases intracellular iron ions level in Huh-7/Hep3B cells.
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Bax plays a key role in ARS-induced intrinsic apoptosis in Huh-7 and Hep3B cells.