mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer

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• 作者：Andrew M. Hau^a ; Mariah Z. Leivo^a ; Andrew S. Gilder^a ; Jing-Jing Hu^a ; Steven L. Gonias^a ; Donna E. Hansel^a ; ^b ; ^{dhansel@ucsd.edu}
• 关键词：mTORC2 ; Urokinase-type plasminogen activator ; uPAR ; Akt ; Cell migration
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：29
• 期：Complete
• 页码：96-106
• 全文大小：1930 K
• 卷排序：29

文摘

uPAR is upregulated in invasive bladder cancer cells. uPAR functions as a major upstream activator of mTORC2 in bladder cancer. Alternative enzymes that phosphorylate Akt S473 are de-repressed in PTEN deficient cells.