Antiproliferative and ultrastructural effects of phenethylamine derivatives on promastigotes and amastigotes of Leishmania (Leishmania) infantum chagasi

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• 作者：Paula Ferreira Brasil^a ; ^b ; J&uacute ; lia Ara&uacute ; jo de Freitas^a ; Anna Lé ; a Silva Barreto^a ; Camila Marques Adade^a ; Leandro Figueira Reis de Sá ; ^a ; Pamella Constantino-Teles^a ; Fabiano Travanca Toledo^c ; Bruno A. de Sousa^c ; Augusto Cesar Gonç ; alves^c ; Maria Teresa Villela Romanos^e ; Joã ; o V. Comasseto^c ; ^d ; Alcindo A. dos Santos^c ; Ana Claudia Tessis^b ; Thais Souto-Padró ; n^a ; ^f ; ¹ ; Rosangela Maria A. Soares^a ; Antonio Ferreira-Pereira^a ; ^{apereira@micro.ufrj.br}
• 关键词：L. chagasi ; Phenethylamine ; Cellular damage
• 刊名：Parasitology International
• 出版年：2017
• 出版时间：April 2017
• 年：2017
• 卷：66
• 期：2
• 页码：47-55
• 全文大小：1481 K
• 卷排序：66

文摘

Synthetic phenetylamine derivatives work as leishmanicidal in both evolutive forms. The compounds inhibit growth and may cause several cellular structural effects. The most effective phenetylamine derivative showed a low toxicity to mammal cells. These findings provide new perspectives to study synthetic phenetylamine as a possible drug to treat leishmanioses.