Histamine H₃ receptor activation stimulates calcium mobilization in a subpopulation of rat striatal neurons in primary culture, but not in synaptosomes

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• 作者：Nayeli Rivera-Ram&iacute ; rez^a ; Wilber Montejo-Ló ; pez^a ; Mar&iacute ; a-Cristina Ló ; pez-Mé ; ndez^b ; Agust&iacute ; n Guerrero-Herná ; ndez^b ; Anayansi Molina-Herná ; ndez^c ; Ubaldo Garc&iacute ; a-Herná ; ndez^a ; José ; -Antonio Arias-Montañ ; o^a ; ^{jaarias@fisio.cinvestav.mx}
• 关键词：Histamine ; H3 receptor ; Striatum ; Calcium mobilization ; Primary culture ; Synaptosomes
• 刊名：Neurochemistry International
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：101
• 期：Complete
• 页码：38-47
• 全文大小：1619 K
• 卷排序：101

文摘

Histamine H3 receptors (H3Rs) are abundantly expressed in the mammalian brain. H3R activation has no effect on the [Ca2+]i of rat striatal synaptosomes. H3R activation stimulates IP3 formation in rat striatal primary cultures. H3R activation increases the [Ca2+]i of striatal neurons in primary culture. H3Rs activate the PLC/IP3/Ca2+ pathway in a subpopulation of striatal neurons.