Effects of alprazolam and cannabinoid-related compounds in an animal model of panic attack
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- 作者：Luara A. Batistaa ; Andrea S. Haibarab ; Luiz C. Schenbergc ; Fabricio A. Moreirad ; fabriciomoreira@icb.ufmg.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Panic ; Aversion ; Chemoreflex ; Cannabinoid ; CB1 receptor ; Benzodiazepines
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：508-514
- 全文大小：460 K
文摘
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The pharmacological treatment of panic disorder is limited.
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One of the few animal models of panic is the response to KCN injection in rats.
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The KCN model is useful for screening new potential treatments for panic disorder.
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Cannabinoid compounds, which may alleviate anxiety, failed to inhibit KCN effects.
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Alprazolam, a benzodiazepine, abolished KCN behavioral and cardiovascular effects.