In the present study, we determined receptor specific effects on intracellular cAMP levels, signaling by western blot analysis and apoptosis by using JC-1 and Hoechst-33258 staining. Here, we present the data which indicates that SST inhibits isoproterenol induced hypertrophy and apoptosis in H9c2 cells. Importantly, SST inhibits ¦Â-ARs agonist induced cAMP activation and SST mediated inhibition of cAMP was enhanced in presence of ¦Â-ARs antagonist. SST enhances ¦Â2AR agonist formoterol mediated effects on PKA, CREB and ERK1/2 phosphorylations whereas it inhibits isoproterenol mediated ERK1/2 and p38 signaling in concentration dependent manner.
Taken together, these results presented here provide a novel insight for the potential role of SST in regulation of ¦Â-AR mediated effects on hypertrophy and modulation of hypertrophy promoting signaling in H9c2 cells.