In vitro effects of sex hormones in human meibomian gland epithelial cells
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- 作者：Antje Schrö ; dera ; Daniel B. Abrara ; Ulrike Hampela ; b ; Martin Schichta ; Friedrich Paulsena ; Fabian Garreisa ; fabian.garreis@fau.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Human meibomian gland epithelial cell line (HMGEC) ; Meibomian gland dysfunction (MGD) ; Dry eye disease (DED) ; Androgen ; Estradiol ; Ocular surface ; Tear film ; Hornerin (HRNR)
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：151
- 期：Complete
- 页码：190-202
- 全文大小：4203 K
文摘
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Protein expression of sex hormone receptors in cultivated HMGEC.
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Expression of progesterone receptor (PR), estrogen receptors (ER)α and -β was induced under cultivation with fetal calf serum.
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DHT and β-Est had no effect on cellular morphology and lipid accumulation.
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Sex hormones and calcium altered gene expression of MGD-associated markers, especially keratinization genes .