Multiple irradiation sensing of the optical effective attenuation coefficient for spectral correction in handheld OA imaging

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• 作者：K. Gerrit HeldAuthor Vitae ; Michael JaegerAuthor Vitae ; Jaro RičkaAuthor Vitae ; Martin Frenz ; ^{Martin.Frenz@iap.unibe.ch" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; H. Gü ; nhan Akarç ; ayAuthor Vitae
• 关键词：Optoacoustic ; Quantitative optoacoustic imaging ; Fluence compensation ; Spectral correction ; Multiple irradiation sensing ; Light diffusion ; Blood oxygenation saturation
• 刊名：Photoacoustics
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：4
• 期：2
• 页码：70-80
• 全文大小：2658 K

文摘

Spectral optoacoustic (OA) imaging enables spatially-resolved measurement of blood oxygenation levels, based on the distinct optical absorption spectra of oxygenated and de-oxygenated blood. Wavelength-dependent optical attenuation in the bulk tissue, however, distorts the acquired OA spectrum and thus makes quantitative oxygenation measurements challenging. We demonstrate a correction for this spectral distortion without requiring a priori knowledge of the tissue optical properties, using the concept of multiple irradiation sensing: recording the OA signal amplitude of an absorbing structure (e.g. blood vessel), which serves as an intrinsic fluence detector, as function of irradiation position. This permits the reconstruction of the bulk effective optical attenuation coefficient μ_eff,λ. If performed at various irradiation wavelengths, a correction for the wavelength-dependent fluence attenuation is achieved, revealing accurate spectral information on the absorbing structures. Phantom studies were performed to show the potential of this technique for handheld clinical combined OA and ultrasound imaging.