文摘
Four novel N-aryloxazol-2-amine CLK1 inhibitors (20,30,40,80 nM) were discovered. Their binding poses in CLK1 and 3 were predicted. Analysis of all CLK PDB structures and interactions of their ligands were performed. An advantageous dual VEGFR2/CLK activity of N-aryloxazol-2-amines was proposed.