- 作者：J.E. Machado-Alba ; machado@utp.edu.co" class="auth_mail" title="E-mail the corresponding author ; L.F. Calvo-Torres ; S. Garcí ; a-Betancur ; A. Aguirre-Novoa ; A.M. Bañ ; ol-Giraldo
- 关键词：Antiepileptics ; Drug prescription ; Therapeutic uses ; Drug utilisation ; Pharmacoepidemiology ; Colombia
- 刊名：Neurología (English Edition)
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：31
- 期：2
- 页码：89-96
- 全文大小：571 K
Methods
Retrospective cross-sectional study. From the pool of individuals in 34 Colombian cities who used antiepileptic drugs between 18 July 2013 and 31 August 2014 during a period of no less than 12 months, we obtained a random sample stratified by city. Socio-demographic, pharmacological and comorbidity variables were analysed. Continuous and categorical variables were compared, and logistic regression models were used.
Results
Our patient total was 373 patients, with 197 women (52.1%) and a mean age of 41.9 ± 21.7 years; 65.4% of the patients were treated with monotherapy. The most frequently used drugs were valproic acid (53.1%) and carbamazepine (33.2%). Epilepsy was the most frequent indication (n = 178; 47.7%); however, 52.3% of the patients were prescribed antiepileptics for different indications, especially neuropathic pain (26.8%), affective disorders (14.2%) and migraine prophylaxis (12.3%). A total of 81 patients with epilepsy (46.6%) displayed good seizure control while another 25 (14.4%) had drug-resistant epilepsy. In the multivariate analysis, medication adherence was associated with a lower risk of treatment failure in patients with epilepsy (OR: 0.27; 95% CI: 0.11-0.67).
Conclusions
In Colombia, antiepileptic drugs are being used for indications other than those originally intended. Monotherapy is the most commonly used treatment approach, together with the use of classic antiepileptic drugs.