LIN41 Post-transcriptionally Silences mRNAs by Two Distinct and Position-Dependent Mechanisms

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• 作者：Florian Aeschimann¹ ; ² ; Pooja Kumari¹ ; Hrishikesh Bartake¹ ; ² ; Dimos Gaidatzis¹ ; ³ ; Lan Xu¹ ; Rafal Ciosk¹ ; Helge Groß ; hans¹ ; ⁴ ; ^{helge.grosshans@fmi.ch}
• 关键词：heterochronic ; EGR ; RNA-binding protein ; stem cell ; translational repression ; mRNA degradation ; 3&prime ; UTR ; 5&prime ; UTR ; ribosome profiling ; positional effect
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：65
• 期：3
• 页码：476-489.e4
• 全文大小：3709 K
• 卷排序：65

文摘

Ribosome profiling and RNA immunoprecipitation identify direct targets of LIN41 Three mRNAs undergo LIN41-dependent decay, one undergoes pure translational repression The location of LIN41 binding on the mRNA determines the choice of mechanism LIN-29A/EGR and MAB-10/NAB may be evolutionarily conserved LIN41 targets