Concomitant helminth infection downmodulates the Vaccinia virus-specific immune response and potentiates virus-associated pathology

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• 作者：Pedro Henrique Gazzinelli-Guimarã ; es^a ; Lorena Falabella Daher de Freitas^b ; Ana Clara Gazzinelli-Guimarã ; es^a ; Fabiana Coelho^b ; Fernando Sé ; rgio Barbosa^a ; Denise Nogueira^a ; Chiara Amorim^a ; Lucas de Carvalho Dhom-Lemos^a ; Luciana Maria Oliveira^a ; Alexandre Barcelos da Silveira^c ; Flá ; vio Guimarã ; es da Fonseca^b ; Lilian Lacerda Bueno^a ; Ricardo Toshio Fujiwara^a ; ^{fujiwara@icb.ufmg.br}
• 关键词：Larval ascariasis ; Vaccinia virus ; co-infection ; Immunomodulation ; Lung inflammation ; Helminth immunology
• 刊名：International Journal for Parasitology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：47
• 期：1
• 页码：1-10
• 全文大小：2346 K
• 卷排序：47

文摘

Ascaris sp. and Vaccinia virus (VACV) co-infection aggravates the virus-associated pathology. Ascaris sp. and VACV co-infection enhances virus titres in the lung, leading to a marked increase in mortality. A reduction in CD4+IFN-γ+ T cells is associated with increased morbidity in co-infection. There is a negative association between the coincident larval Ascaris and respiratory VACV infection. Co-infected mice presented a marked decrease in the total number of migrating Ascaris lung-stage larvae.