A facile diversity-oriented synthesis of imidazo[1,2-a]pyrazinones via?gold-catalyzed regioselective heteroannulation of propynylaminopyrazinones

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• 作者：Dipak D. Vachhani ; Sachin G. Modha ; Abhishek Sharma^&dagger ; ; Erik V. Van der Eycken ; ^{erik.vandereycken@chem.kuleuven.be}
• 关键词：Gold ; Heteroannulation ; Imidazopyrazinone ; Alkyne ; Suzuki
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：7 January, 2013
• 年：2013
• 卷：69
• 期：1
• 页码：359-365
• 全文大小：558 K

文摘

A gold-catalyzed regioselective heteroannulation strategy has been developed for the concise and efficient synthesis of imidazo[1,2-a]pyrazinones. The protocol allows the introduction of diversity via the application of substituted propargyl amines or via Suzuki-coupling of the generated imidazo[1,2-a]pyrazinones with various (het)aryl boronic acids.