Activation of the IL-1β/CXCL1/MMP-10 axis in chorioamnionitis induced by inactivated Group B Streptococcus
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- 作者：Julie Bergerona ; Julie.L.Bergeron@USherbrooke.ca" class="auth_mail" title="E-mail the corresponding author ; Noha Gergesb ; ngerges7@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Clé ; mence Guirautb ; Clemence.Guiraut2@mail.mcgill.ca" class="auth_mail" title="E-mail the corresponding author ; Djordje Grbica ; Djordje.Grbic@Usherbrooke.ca" class="auth_mail" title="E-mail the corresponding author ; Marie-Julie Allardb ; Louis-Charles Fortierc ; Louis-Charles.Fortier@USherbrooke.ca" class="auth_mail" title="E-mail the corresponding author ; Cathy Vaillancourtd ; cathy.vaillancourt@iaf.inrs.ca" class="auth_mail" title="E-mail the corresponding author ; Guillaume Sé ; birea ; b ; Guillaume.Sebire@mcgill.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chorioamnionitis ; Maternal immune activation ; Group B Streptococcus ; Placenta ; Inflammation ; Interleukin-1β
- 刊名：Placenta
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：47
- 期：Complete
- 页码：116-123
- 全文大小：2745 K
文摘
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GBS-induced chorioamnionitis is associated to IL-1/CINC-1-driven PMN infiltration, MMP-10 release, and IL-1 secretion within the fetus blood.
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IL-1 is likely the key player in the onset of chorioamnionitis to be targeted in future placento-protective strategies.
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This results pave the way toward targeted anti-inflammatory treatments to protect the placenta and associated multi-organ threats.