Functional Plasticity of the AgrC Receptor Histidine Kinase Required for Staphylococcal Virulence

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• 作者：Boyuan Wang¹ ; ² ; ⁵ ; ⁶ ; Aishan Zhao¹ ; ⁵ ; Qian Xie¹ ; Paul Dominic Olinares³ ; Brian T. Chait³ ; Richard P. Novick⁴ ; Tom W. Muir¹ ; ⁷ ; ^{muir@princeton.edu}
• 关键词：Staphylococcus aureus ; constitutive mutant ; input-response property ; two-component signaling ; phospho-transfer ; agr ; quorum sensing ; allelic variation ; transmembrane histidine kinase ; nanodisc
• 刊名：Cell Chemical Biology
• 出版年：2017
• 出版时间：19 January 2017
• 年：2017
• 卷：24
• 期：1
• 页码：76-86
• 全文大小：3397 K
• 卷排序：24

文摘

AgrC activity correlates with the timing of agr induction among S. aureus subgroups Single mutations in AgrC produce constitutive mutants by modifying the response curve AgrC constitutive mutants differ in phospho-transfer rate with non-cognate AIP bound