The study included 48 patients (mean age 59 ± 10 years) with mild-to-moderate hypertension, according to JNC VI and who did not present any associated diseases. We determined the following in all patients: Ca, P, Mg, PTHi, 25-vitamin D, 1,25-vitamin D, osteocalcin, deoxypyridinoline in urine, 24-h urine calcium. A bone densitometry of the lumbar spine was also performed. CaSR gene A986S polymorphism was also studied in all patients by PCR.
Genotype frequency was 69 % for AA, 27 % for AS and 4 % for SS, with a prevalence of 82 % for allele A and 18 % for allele S. Patients with a lack of allele S had lower levels of p (3.5 ± 0.5 vs. 4 ± 0.4, p = .034). No differences in calcium plasma levels, urinary calcium excretion and bone mass were observed.
We found no clinical significance in the parameters studied of the CaSR gene A986S polymorphism in hypertensive women.