The TIR/BB-loop mimetic AS-1 attenuates mechanical stress-induced cardiac fibroblast activation and paracrine secretion via modulation of large tumor suppressor kinase 1
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- 作者：Min Fana ; 1 ; Juan Songa ; 1 ; Yijie Hea ; Xin Shena ; Jiantao Lia ; Linli Quea ; Guoqing Zhub ; Quan Zhuc ; Xin Caid ; Tuanzhu Hae ; Qi Chena ; Yong Xua ; Chuanfu Lie ; Yuehua Lia ; yhli@njmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AS-1 ; hydrocinnamoyl-l-valylpyrrolidine ; TIR ; Toll/interleukin-1 receptor ; IL-1R ; interleukin-1 receptor ; MyD88 ; myeloid differentiation primary response gene 88 ; MS ; mechanical stress ; LATS1 ; large tumor suppressor kinase 1 ; YAP ; Yes associated protein ; NRCFs ; neonatal rat cardiac fibroblasts ; NRVMs ; neonatal rat ventricular myocytes ; TAC ; transverse aortic constriction ; TNF-α ; tumor necrosis factor-α ; IL-1β ; interleukin-1β ; Sav ; salvador ; MST1/2 ; Mammalian sterile 20-like kinase 1/2 ; Mob1 ; mps
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1862
- 期：6
- 页码：1191-1202
- 全文大小：5106 K
文摘
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AS-1 attenuates mechanical stress-induced decreases of LATS1 in cardiac fibroblasts and in vivo.
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AS-1 inhibits mechanical stress-induced cardiac fibroblast activity via LATS1.
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AS-1 inverses cardiomyocyte hypertrophy induced by fibroblast paracrine and LATS1 modulates pro-hypertrophic signal.
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AS-1 ameliorates pressure overload-induced cardiac fibrosis and heart failure.