A cold water extract of Fucus vesiculosus inhibits lipopolysaccharide (LPS) induced pro-inflammatory responses in the porcine colon ex-vivo model
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- 作者：Bojlul Bahara ; John V. O&rsquo ; Dohertya ; Thomas J. Smythb ; c ; Albin M. Ahmedd ; Torres Sweeneyd ; torres.sweeney@ucd.ie" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fucus ; Functional food ; Gene expression ; Marine bioactives ; Intestine
- 刊名：Innovative Food Science & Emerging Technologies
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：37
- 期：part_PB
- 页码：229-236
- 全文大小：494 K
文摘
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Anti-inflammatory activity of three extracts of F. vesiculosus were evaluated.
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Cold water extract (CWE) of F. vesiculosus exhibited strong anti-inflammatory activity in-vitro.
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CWE down-regulated the expression of inflammatory markers in porcine colonic tissue ex-vivo.
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Effects of the CWE were mediated through inhibition of NF-κB, MAPK and AP-1 pro-inflammatory pathways.