Comparison of trophic factors' expression between paralyzed and recovering muscles after facial nerve injury. A quantitative analysis in time course
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- 作者：Maria Groshevaa ; 1 ; Klaus Nohroudib ; 1 ; Alisa Schwarzb ; Svenja Rinkb ; Habib Bendellac ; Levent Sarikcioglud ; Lars Klimaschewskie ; Tessa Gordonf ; 2 ; Doychin N. Angelovb ; 2 ; angelov.anatomie@uni-koeln.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Motoneuron ; Axotomy ; Functional recovery ; Vibrissae whisking ; Motor endplates ; Polyinnervation ; NGF ; BDNF ; IGF ; FGF2 ; RT-PCR ; ELISA
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：279
- 期：Complete
- 页码：137-148
- 全文大小：1189 K
文摘
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Blind rats from the SD/RCS strain recover whisking after facial nerve injury.
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We studied the expression of BDNF, FGF2 IGF1, IGF2 and NGF in denervated muscles.
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We compared the amounts to those obtained in sighted rats (no functional recovery).
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In the blind rats we found an early increase in FGF2 and a concomitant decrease in NGF.
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FGF2-increase and NGF-decrease prevent the distal branching of regenerating axons.
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This in turn reduces poly-innervation of NMJ and promotes functional recovery.