Two mutations in the vif gene of maedi-visna virus have different phenotypes, indicating more than one function of Vif
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- 作者：Sigrí ; dur R. Franzdó ; ttira ; Katrí ; n Ó ; lafsdó ; ttira ; Stefá ; n R. Jó ; nssona ; Hannah Strobela ; Ó ; lafur S. André ; ssonb ; Valgerdur André ; sdó ; ttira ; valand@hi.is" class="auth_mail" title="E-mail the corresponding author
- 关键词：Maedi-visna virus ; Lentivirus ; Vif ; Capsid ; APOBEC3 ; Host restriction
- 刊名：Virology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：488
- 期：Complete
- 页码：37-42
- 全文大小：464 K
文摘
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The role of MVV Vif in neutralizing ovine APOBEC3Z2–Z3 is confirmed.
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A W98R mutation in Vif disrupts Vif-APOBEC3Z2-Z3 interaction.
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A P205S mutation in Vif together with a mutation in CA impairs virus replication.
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The phenotype of the CA(L120R)-Vif(P205S) double mutant is cell-type specific.
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No hypermutation is associated with the CA(L120R)-Vif(P205S) phenotype.