Lupeol derivative mitigates Echis carinatus venom-induced tissue destruction by neutralizing venom toxins and protecting collagen and angiogenic receptors on inflammatory cells
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- 作者：G.D. Katkara ; Rachana D. Sharmaa ; G.J. Vishalakshia ; S.K. Naveenkumara ; Gaurav Madhurb ; R.M. Thusharaa ; T. Narenderb ; t_narendra@cdri.res.in" class="auth_mail" title="E-mail the corresponding author ; K.S. Girisha ; 1 ; ksgbaboo@gmail.com" class="auth_mail" title="E-mail the corresponding author ; K. Kemparajua ; kemparajuom@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：E. carinatus ; Venom ; Local toxicity ; Lupeol ; Collagen receptors ; Inflammatory cells
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：1850
- 期：12
- 页码：2393-2409
- 全文大小：3656 K
文摘
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Compound 8, a synthetic lupeol derivative inhibited
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Collagen and chemokine receptors of inflammatory cells are essential to resolve inflammation and to promote tissue repair.
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Compound 8 not only protect collagen receptors and CX3CR1 on these cells, but also inhibit venom-induced oxidative stress.