Feasibility study of dual-targeting paclitaxel-loaded magnetic liposomes using electromagnetic actuation and macrophages
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- 作者：Van Du NguyenAuthor Vitae ; Jiwon HanAuthor Vitae ; Gwangjun GoAuthor Vitae ; Jin ZhenAuthor Vitae ; Shaohui ZhengAuthor Vitae ; Viet Ha LeAuthor Vitae ; Jong-Oh Park ; jop@jnu.ac.krAuthor Vitae ; Sukho Park ; spark@jnu.ac.krAuthor Vitae
- 关键词：Macrophage ; Cell-mediated drug delivery ; Liposome ; Magnetic nanoparticle ; Tumor targeting
- 刊名：Sensors and Actuators B: Chemical
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：240
- 期：Complete
- 页码：1226-1236
- 全文大小：2863 K
- 卷排序：240
文摘
Dual targeting biomimetic macrophage-based drug delivery system to tumor is developed. Anticancer drug loaded magnetic liposomes are engulfed in to macrophages. The system is controlled by electromagnetic field through blood vessels. The system can cross the blood barriers and infiltrate to tumor using macrophage’s chemotaxis. Drug release from liposomes simultaneously kills macrophages and tumor cells.