Vital Capacity Impairment due to Neuromuscular Disease and its Correlation with Diaphragmatic Ultrasound: A Preliminary Study

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• 作者：Cé ; dric Carrié ; ^&lowast ; ; ^{cedric.carrie@chu-bordeaux.fr" class="auth_mail" title="E-mail the corresponding author} ; Eline Bonnardel^&dagger ; ; Rishad Vally^&lowast ; ; Philippe Revel^&lowast ; ; Roger Marthan^&Dagger ; ; ^§ ; ; Matthieu Biais^&dagger ; ; ^§ ;
• 关键词：Diaphragmatic excursion ; Diaphragmatic ultrasound ; Bedside ultrasound ; Pulmonary function ; Neuromuscular disease
• 刊名：Ultrasound in Medicine & Biology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：42
• 期：1
• 页码：143-149
• 全文大小：557 K

文摘

The purpose of this pilot study was to evaluate the correlation between diaphragmatic excursion measured by a right sub-costal ultrasound approach and forced vital capacity in patients with amyotrophic lateral sclerosis (ALS) or myotonic dystrophy (MD). All patients referred for pulmonary function testing underwent ultrasonic measurement of diaphragmatic excursion during quiet breathing, voluntary sniffing (E_sniff) and forced breathing (EDE_max). Forty-five patients were included, mainly for amyotrophic lateral sclerosis or myotonic dystrophy. There was a significant correlation between EDE_max values and forced vital capacity (FVC) values (r = 0.68 [0.46–0.90], p < 0.0001) and between EDE_max values and percentage of predicted FVC values (r = 0.75 [0.55–0.95], p < 0.0001). At a threshold of EDE_max < 5.5 cm, the sensitivity and specificity of ultrasonic diaphragmatic excursion in predicting FVC ≤ 50% of theoretical values were 100% [66%–100%] and 69% [52%–84%] respectively, without any significant difference between males and females. There was no statistical correlation between maximal inspiratory pressure and E_sniff.