1,25-Dihydroxy vitamin D₃ stimulates system A amino acid transport in primary human trophoblast cells

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• 作者：Yi-Yung Chen^a ; ^c ; ^{yhyy@mmh.org.tw} ; Theresa L. Powell^a ; ^b ; Thomas Jansson^a
• 关键词：Placenta ; Nutrient transport ; Fetal growth ; Maternal-fetal exchange
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：442
• 期：Complete
• 页码：90-97
• 全文大小：1018 K
• 卷排序：442

文摘

Effects of vitamin D on primary human trophoblast amino acid transport were studied. 1,25-dihydroxy vitamin D3 increased mRNA expression of the System A isoform SNAT2. 1,25-dihydroxy vitamin D3 stimulated system A amino acid transport activity. Trophoblast mTOR signaling was not regulated by1,25-dihydroxy vitamin D3. Altered placental amino acid transport may link maternal vitamin D to fetal growth.