In silico assessment of adverse drug reactions and associated mechanisms
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- 作者：Sergey M. Ivanov1 ; 2Author Vitae ; Alexey A. Lagunin1 ; 2Author Vitae ; Vladimir V. Poroikov1 ; 2 ; vladimir.poroikov@ibmc.msk.ru" class="auth_mail" title="E-mail the corresponding author ; vvp1951@yandex.ru" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 刊名：Drug Discovery Today
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：21
- 期：1
- 页码：58-71
- 全文大小：1586 K
文摘
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Early assessment of adverse drug reactions (ADRs) requires knowledge of their mechanisms.
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Chemical and biological drug features can be used for assessment of mechanisms.
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Predicted protein targets, genes, pathways, chemical fragments are used in ADR analysis.
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Network and pathway analysis reveal true associations of features with ADR mechanisms.
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Predictive models for adverse reactions can be created based on revealed features.