Activated immune-inflammatory pathways are associated with long-standing depressive symptoms: Evidence from gene-set enrichment analyses in the Young Finns Study
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- 作者：Marko Elovainioa ; b ; marko.elovainio@thl.fi" class="auth_mail" title="E-mail the corresponding author ; Tuukka Taipalec ; Ilkka Seppä ; lä ; c ; Nina Mononenc ; Emma Raitoharjuc ; Markus Jokelaa ; Laura Pulkki-Rå ; backa ; d ; Thomas Illige ; f ; g ; Melanie Waldenbergere ; Christian Hakulinena ; Taina Hintsaa ; Mika Kivimä ; kih ; i ; Mika Kä ; hö ; nenj ; Liisa Keltikangas-Jä ; rvinena ; Olli Raitakarik ; l ; Terho Lehtimä ; kic
- 关键词：Gene set pathways ; Gene-set enrichment analyses ; Gene expression depression
- 刊名：Journal of Psychiatric Research
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：71
- 期：Complete
- 页码：120-125
- 全文大小：259 K
文摘
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Inflammation has been shown to be associated with depressive symptoms, but the molecular mechanisms are not known.
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We used Gene Set Enrichment Analysis and analytical methods to examine the molecular mechanisms in depressive symptoms.
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Depressive symptoms were associated with differences in regulatory pathways that were associated with inflammatory processes.