Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: The cardiovascular risk in Young Finns Study
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- 作者：Emma Raitoharjua ; emma.raitoharju@uta.fi" class="auth_mail ; Ilkka Seppä ; lä ; a ; Niku Oksalaa ; b ; Leo-Pekka Lyytikä ; inena ; Olli Raitakaric ; d ; Jorma Viikarie ; Mika Ala-Korpelaf ; g ; h ; i ; Pasi Soininenf ; g ; Antti J. Kangasf ; g ; Melanie Waldenbergerj ; Norman Kloppj ; k ; Thomas Illigj ; k ; Jaana Leiviskä ; l ; Britt-Marie Lool ; Nina Hutri-Kä ; hö ; nenm ; Mika Kä ; hö ; nenn ; Reijo Laaksonena ; Terho Lehtimä ; kia
- 关键词：MicroRNA ; Metabolic syndrome ; Diabetes ; MRNA expression ; NMR metabolomics
- 刊名：Molecular and Cellular Endocrinology
- 出版年：25 June 2014
- 年：2014
- 卷：391
- 期：1-2
- 页码：41-49
- 全文大小：744 K
文摘
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Nine miRNAs associated with 14 metabolites associated with MetS or it components.
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Targets of miR-1207-5p and -129-2-3p were enriched in 8 pathways down-regulated in MetS.
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MiR-129-3p and -1207-5p may play a role in glucose and lipid metabolism.