Differences in protein binding and excretion of Triapine and its Fe(III) complex
详细信息 查看全文
- 作者：Karla Pelivana ; Walter Miklosb ; Sushilla van Schoonhovenb ; Gunda Koellenspergerd ; Lars Gillee ; Walter Bergerb ; c ; Petra Heffeterb ; c ; petra.heffeter@meduniwien.ac.at" class="auth_mail" title="E-mail the corresponding author ; Christian R. Kowola ; c ; christian.kowol@univie.ac.at" class="auth_mail" title="E-mail the corresponding author ; Bernhard K. Kepplera ; c
- 关键词：Drug development ; Thiosemicarbazones ; Triapine ; Pharmacokinetics ; In vivo
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：160
- 期：Complete
- 页码：61-69
- 全文大小：747 K
文摘
- •
Triapine has been investigated in more than 30 clinical trials.
- •
Unknown reasons for inactivity against solid tumors
- •
Difference in pharmacological properties between Triapine and Fe-Triapine
- •
High protein binding affinity of Fe-Triapine in contrast to Triapine