Fluorofenidone protects mice from lethal endotoxemia through the inhibition of TNF-α and IL-1β release

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• 作者：Yiting Tang ; Bingxin Li ; Nasui Wang ; Yanyun Xie ; Linghao Wang ; Qiongjing Yuan ; Fangfang Zhang ; Jiao Qin ; Zhangzhe Peng ; Wangbin Ning ; Ling Wang ; Gaoyun Hu ; Jing Li ; Lijian Tao
• 关键词：Inflammation ; Sepsis ; Endotoxemia
• 刊名：International Immunopharmacology
• 出版年：2010
• 出版时间：May 2010
• 年：2010
• 卷：10
• 期：5
• 页码：580-583
• 全文大小：334 K

文摘

The pathogenesis of sepsis is mediated in part by bacterial endotoxin, which stimulates macrophages/monocytes to sequentially release proinflammatory factors like TNF-α and IL-1β. Fluorofenidone (AKF-PD) is a novel pyridone agent, which exerts a strong antifibrotic effect. In this work, we showed that AKF-PD also exert an inhibitory effect on acute systemic inflammatory response. AKF-PD treatment significantly increased survival in animals with established endotoxemia. In addition, AKF-PD treatment significantly reduced circulating levels of TNF-α and IL-1β during endotoxemia. In macrophage cultures, AKF-PD inhibited the release of TNF-α and IL-1β in a dose-dependent manner. In conclusion, these results indicate that AKF-PD inhibits the release of the proinflammatory cytokines (TNF-a and IL-1β) and improves survival during lethal endotoxemia, which suggest this new pyridone agent can be a novel candidate for therapy of septic shock.