CPSF4 activates telomerase reverse transcriptase and predicts poor prognosis in human lung adenocarcinomas
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- 作者：Wangbing Chena ; 1 ; Lijun Qinb ; 1 ; Shusen Wanga ; wangshs@sysucc.org.cn" class="auth_mail ; Mei Lia ; Dingbo Shia ; Yun Tiana ; Jingshu Wanga ; Lingyi Fua ; Zhenglin Lic ; Wei Guoc ; Wendan Yuc ; Yuhui Yuanc ; Tiebang Kanga ; Wenlin Huanga ; d ; huangwl@sysucc.org.cn" class="auth_mail ; Wuguo Denga ; d ; dengwg@sysucc.org.cn" class="auth_mail
- 关键词：CPSF4 ; Telomerase ; hTERT ; Promoter ; Lung cancer
- 刊名：Molecular Oncology
- 出版年：May 2014
- 年：2014
- 卷：8
- 期：3
- 页码：704-716
- 全文大小：2809 K
文摘
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We discover and identify CPSF4 as a novel hTERT promoter-regulating factor in lung cancer cells.
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CPSF4 upregulates hTERT promoter activity, hTERT expression and telomerase activity.
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Knockdown of CPSF4 inhibits lung cancer growth by downregulating hTERT expression and activity.
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CPSF4 and hTERT are highly expressed in lung cancer cells and adenocarcinoma tumor tissues.
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CPSF4 and hTERT overexpression is associated with poor progonsis in lung adenocarcinoma patient.
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