Prior stressor exposure delays the recovery of surgery-induced cognitive impairment and prolongs neuroinflammation in aged rats
详细信息 查看全文
- 作者：Yaxuan Wang1 ; yaxuanwangcmu@126.com" class="auth_mail" title="E-mail the corresponding author ; Xuezhao Cao2 ; xuezhaocao2011@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Hong Ma ; 3 ; mahong5466@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Wenfei Tan4 ; winfieldtan@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Lingwei Zhang5 ; weilingwei1989@126.com" class="auth_mail" title="E-mail the corresponding author ; Zhe Li6 ; jllizhe@126.com" class="auth_mail" title="E-mail the corresponding author ; Yalei Gao6 ; yaleigao@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Postoperative cognitive dysfunction (POCD) ; Prior stress ; Inescapable tailshock (IS) ; Neuroinflammation ; Hippocampus ; Aging
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：1648
- 期：part_PA
- 页码：380-386
- 全文大小：3459 K
文摘
- •
Surgery disrupted cognitive function and increased pro-inflammatory cytokines.
- •
IS prolonged pro-inflammatory response to the subsequent surgery challenge.
- •
IS delayed the recovery of surgery-induced cognitive impairment.
- •
IS shifted the neuroimmune microenvironment toward a microglial activation state.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |