Molecular cloning and functional characterization of porcine E74-like factor 4 (ELF4)
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- 作者：Yanling Shia ; b ; Dang Wanga ; b ; wangdang511@126.com" class="auth_mail" title="E-mail the corresponding author ; wangdang@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xinyu Zhua ; b ; Qiong Wua ; b ; Huanchun Chena ; b ; Shaobo Xiaoa ; b ; Liurong Fanga ; b ; fanglr@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：E74-like factor 4 (ELF4) ; Porcine ; Interferon ; Signaling pathway
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：149-158
- 全文大小：2659 K
文摘
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PoELF4 is widely expressed in different tissues, especially the intestine and stomach.
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PoELF4 is involved in the IFN-β signaling pathway in different porcine cells.
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PoELF4 mutant lacking the serine/threonine rich domain still induces IFN-β expression.
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PoELF4 significantly inhibits the replication of both PRV and PRRSV.