Study of the mechanical property and in vitro biocompatibility of CaSiO₃ ceramics

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• 作者：Lin ; Kaili ; Zhai ; Wanyin ; Ni ; Siyu ; Chang ; Jiang ; Zeng ; Yi ; Qian ; Weijun
• 关键词：A. Sintering ; C. Mechanical properties ; Calcium silicate ; Ceramics ; Biocompatibility
• 刊名：Ceramics International
• 出版年：2005
• 出版时间：2005
• 年：2005
• 卷：31
• 期：2
• 页码：323-326
• 全文大小：207 K

文摘

Calcium silicate (CaSiO₃) ceramics were prepared by pressureless sintering. The effects of the sintering temperature and holding time on the mechanical strength, porosity and linear shrinkage of the ceramics, and the adhesion and proliferation of bone marrow mesenchymal stem cells (MMSC) were investigated. When the sintering temperature and holding time increased, the linear shrinkage of the ceramics increased and the porosity decreased. The CaSiO₃ ceramics sintered at 1100 °C for 5 h revealed a mechanical strength of 95.03 ± 7.11 MPa, similar to the bending strength of human cortical bone. In addition, the adhesion and proliferation of MMSC on the CaSiO₃ ceramics was examined and the results showed that the ceramics supported cell adhesion and proliferation, which indicated good biocompatibility. Our results suggested that CaSiO₃ ceramics might be a potential bioactive material as bone implant.