Toxicogenetic evaluation of dichlorophene in peripheral blood and in the cells of the immune system using molecular and flow cytometric approaches
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- 作者：Mohammad Iqbal Lonea ; b ; iqbalzoo84@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Arisa Nabib ; Nawab John Darb ; Aashiq Hussainb ; Nazia Nazama ; Abid Hamidb ; c ; Waseem Ahmada
- 关键词：Dichlorophene ; Comet assay ; Flow cytometry ; Mitochondrial membrane potential ; Cell cycle analysis ; Apoptosis
- 刊名：Chemosphere
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：167
- 期：Complete
- 页码：520-529
- 全文大小：3896 K
文摘
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This is the first report on genotoxicity of Dichlorophene (DCP) using highly sensitive molecular and flow cytomertic approaches.
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Rats treated with DCP induced DNA damage in peripheral blood.
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DCP induces apoptosis and alters mitochondrial membrane potential in leukocytes.
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