Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index

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• 作者：Mirjam V. Faulenbach^a ; ¹ ; Lorena A. Wright^a ; ¹ ; Carlos Lorenzo^b ; ¹ ; Kristina M. Utzschneider^a ; Julia H. Goedecke^c ; Wilfred Y. Fujimoto^a ; Edward J. Boyko^d ; ^e ; Marguerite J. McNeely^c ; Donna L. Leonetti^f ; Steven M. Haffner^b ; Steven E. Kahn^a ; ^{skahn@u.washington.edu} ; American Diabetes Association GENNID Study Group
• 关键词：Oral glucose tolerance test ; Glucose ; Insulin ; Insulinogenic index ; Impaired glucose tolerance ; Diabetes
• 刊名：Journal of Diabetes and its Complications
• 出版年：2013
• 出版时间：March-April, 2013
• 年：2013
• 卷：27
• 期：2
• 页码：158-161
• 全文大小：179 K

文摘

lass=""h4"">Objective

To determine the prevalence of a negative insulinogenic index (change in plasma insulin/change in plasma glucose from 0 to 30 min) from an oral glucose tolerance test according to glucose tolerance category.

lass=""h4"">Materials and Methods

Data from the San Antonio Heart Study (n = 2494), Japanese American Community Diabetes Study (JACDS; n = 594) and Genetics of NIDDM Study (n = 1519) were examined. Glucose tolerance was defined by ADA criteria.

lass=""h4"">Results

In the combined cohort, the prevalence of a negative insulinogenic index was significantly higher in diabetes 20/616 (3.2 % ) compared to normal glucose tolerance 43/2667 (1.6 % ) (p < 0.05). Longitudinally, in the JACDS cohort, the prevalence did not change from baseline (3/594; 0.5 % ) to 5 (4/505; 0.7 % ) and 10 years (8/426; 1.9 % ) (p = 0.9) and no subject had a repeat negative insulinogenic index.

lass=""h4"">Conclusions

A negative insulinogenic index occurs at a low prevalence across glucose tolerance categories although more often in diabetes, but without recurrence over time.