No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels

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• 作者：Pedro Marques-Vidal ; Murielle Bochud ; Fred Paccaud ; Dawn Waterworth ; Sven Bergmann ; Martin Preisig ; Gé ; rard Waeber ; Peter Vollenweider
• 关键词：Lipoproteins ; Epidemiology ; Polymorphisms ; Alcohol consumption ; Gene × ; environment interactions ; HDL
• 刊名：Atherosclerosis
• 出版年：2010
• 出版时间：August 2010
• 年：2010
• 卷：211
• 期：2
• 页码：551-557
• 全文大小：283 K

文摘

Objective

To assess the relationships and possible interactions between polymorphisms related to HDL levels and alcohol consumption.

Methods

Cross-sectional population-based study including 2863 women and 2546 men aged 35–75 years (CoLaus study). Alcohol intake was assessed by the reported alcohol consumption of the last 7 days. Nineteen candidate genes known to influence HDL levels were studied.

Results

Alcohol consumption increased HDL cholesterol levels in both genders. After multivariate adjustment for gender, age, body mass index, smoking, hypolipidaemic drug treatment, physical activity and alcohol consumption, APOA5, CETP, LIPC and LPL gene polymorphisms were significantly (10⁻⁵ threshold) related with HDL cholesterol levels, while no gene × alcohol intake interaction was found for all SNPs studied. ABCA1 polymorphisms were related to HDL cholesterol levels on bivariate analysis but the relationship was no longer significant after multivariate analysis.

Conclusion

Our data confirm the association of alcohol consumption and of APOA5, CETP, LIPC and LPL gene polymorphisms with HDL cholesterol levels. Conversely, no gene × alcohol consumption interactions were found, suggesting that the effect of alcohol consumption on HDL cholesterol levels is not mediated via a modulation of HDL related genes.