Novel ferulic amide derivatives with tertiary amine side chain as acetylcholinesterase and butyrylcholinesterase inhibitors: The influence of carbon spacer length, alkylamine and aromatic group
Many novel ferulic acid amide derivatives with tertiary amine group revealed inhibitory effects against AChE and BuChE. Carbon chain length and tertiary amine side chain markedly influenced the inhibition activity against AChE. If benzamide group was removed or replaced by ethyl ester group, the activity in inhibiting AChE decreased significantly.