Lentinan produces a robust antidepressant-like effect via enhancing the prefrontal Dectin-1/AMPA receptor signaling pathway
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- 作者：Hongkun Baoa ; b ; 1 ; Lijuan Suna ; b ; 1 ; Ying Zhua ; c ; 1 ; Pengzhan Rana ; b ; Weihong Huc ; Keming Zhua ; b ; Bai Lia ; b ; Yangyang Houa ; b ; Jun Niea ; b ; Tangxin Gaoa ; b ; Liping Shand ; Kai Due ; Shangyong Zhengb ; Bingrong Zhengb ; Chunjie Xiaoa ; b ; ; Jing Du ; MD PhDa ; b ; dujing@ynu.edu.cn" class="auth_mail" title="E-mail the corresponding author (Professor)
- 关键词：LNT ; lentinan ; TST ; tail suspension test ; FST ; forced swim test ; OFT ; open field test ; PFC ; prefrontal cortex ; MDD ; Major depressive disorder ; Dectin-1 ; Dendritic cell-associated C-type lectin-1 ; p-GluR1(S845) ; phosphorylation of GluR1 S845 ; AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid ; Lam ; laminarin ; NMDA ; non-competitive N-methyl-d-aspartate ; i.p. ; intraperitonial ; mins ; minutes ; IMI ; imipramine ; BBB ; blood brain barrier ; TLR2 ; toll-like receptor 2 ; Sal ; saline
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：263-271
- 全文大小：1924 K
文摘
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Lentinan treatment led to a robust antidepressant-like effect in the tail suspension test and forced swim test after 60 min of treatment in mice.
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Dectin-1, the receptor of lentinan, mediated the antidepressant-like effects of lentinan.
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The prefrontal Dectin-1/AMPA receptor signaling pathway was essential for the robust antidepressant-like effects evoked by lentinan.