Significant association of GRM7 and GRM8 genes with schizophrenia and major depressive disorder in the Han Chinese population

详细信息    查看全文

• 作者：Wenjin Li¹ ; ^a ; ^b ; ^c ; Kang Ju^d ; ¹ ; Zhiqiang Li^a ; ^b ; ^c ; Kuanjun He^a ; ^b ; ^c ; Jianhua Chen^a ; ^b ; ^c ; ^e ; Qingzhong Wang^a ; ^b ; ^c ; Beimeng Yang^a ; ^b ; ^c ; Lin An^a ; ^b ; ^c ; Guoyin Feng^e ; Weiming Sun^a ; ^b ; ^c ; Juan Zhou^a ; ^b ; ^c ; Shasha Zhang^a ; ^b ; ^c ; Pingping Song^f ; Raja Khan^a ; ^b ; ^c ; Weidong Ji^d ; ^{jidong1999@126.com" class="auth_mail" title="E-mail the corresponding author} ; Yongyong Shi^a ; ^b ; ^c ; ^{shiyongyong@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Schizophrenia ; Major depressive disorder ; GRM7 ; GRM8 ; Association ; SNP
• 刊名：European Neuropsychopharmacology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：26
• 期：1
• 页码：136-146
• 全文大小：1431 K

文摘

Metabotropic glutamate receptor type 7 (GRM7) and type 8 (GRM8) are involved in the neurotransmission of glutamate which is supposed to play an important role in the development of schizophrenia (SCZ) and major depressive disorders (MDD). We designed this study to investigate whether common DNA variants or their genetic interactions within GRM7 and GMR8 genes were associated with these disorders in the Han Chinese population. Fourteen SNPs in GRM7 and GRM8 were selected within a sample set comprising 1235 SCZ patients, 1045 MDD patients and 1235 normal controls. Significant association in SCZ case-control subjects was observed for rs2229902 (permutated P_allele=0.0005, OR=1.492 [95% CI=1.231–1.807]) and rs9870680 (permutated P_allele=0.0023, OR=1.262 [95% CI=1.116–1.426]) in GRM7 and rs2237781 (permutated P_allele=0.0027, OR=1.346 [95% CI=1.149–1.575]) in GRM8. Association analysis for MDD case-control subjects revealed positive results in rs779706 (permutated P_allele=0.0099, OR=1.237 [95% CI=1.093–1.399]) of GRM7 and in rs1361995 (permutated P_allele=0.0017, OR=1.488 [95% CI=1.215–1.823]) of GRM8. Moreover, a three-locus model, constituted by polymorphisms in GRM7 and GRM8 significantly correlated with MDD in the gene–gene interaction analysis. Meta-analysis and haplotype analysis further confirmed our significant results. We demonstrated the genetic association of GRM7 and GRM8 with SCZ and MDD in the Han Chinese population. We also found susceptibility interactive effects of these two genes with both psychiatric disorders, which might provide new insights into the etiology of them.