The effects of the apoE4 genotype on the developing mouse retina
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- 作者：Idit Maharshaka ; b ; Shiran Salomon-Zimria ; Ran Antesa ; Ori Liraza ; Yael Nisgavc ; Tami Livnatc ; Dov Weinbergerb ; e ; Carol A. Coltonf ; Arieh S. Solomonb ; d ; Daniel M. Michaelsona ; dmichael@post.tau.ac.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apolipoprotein E4 (apoE4) ; Retina ; Targeted replacement mice ; Vascular endothelial growth factor (VEGF) ; Vasculature
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：145
- 期：Complete
- 页码：17-25
- 全文大小：2216 K
文摘
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ApoE4 induces retinal vascular pathology transiently in P4 neonate mice.
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ApoE4 induces retinal synaptic pathology starting at P12 neonate mice.
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ApoE4 driven retinal vascular pathology correlate temporally with low levels of apoE.
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ApoE4 driven retinal pathology is associated with decreased levels of VEGF.