Serotonin type-1D receptor stimulation of A-type K+ channel decreases membrane excitability through the protein kinase A- and B-Raf-dependent p38 MAPK pathways in mouse trigeminal ganglion neurons
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- 作者：Xianyang Zhaoa ; 1 ; Yuan Zhangb ; d ; 1 ; Wenjuan Qina ; 1 ; Junping Caoa ; Yi Zhanga ; Jianqiang Nia ; Yangang Sunc ; Xinghong Jianga ; Jin Taoa ; b ; taoj@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HT1D receptor ; A-type K+ currents (IA) ; Neuronal excitability ; Trigeminal ganglion (TG) neurons
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：28
- 期：8
- 页码：979-988
- 全文大小：1446 K
文摘
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The 5-HT1B/D agonist sumatriptan selectively enhances IA in a concentration-dependent manner.
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The 5-HT1D, but not 5-HT1B, induces IA increase in small-sized TG neurons.
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The Gβγ-dependent protein kinase A is required in the 5-HT1D-mediated response.
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The 5-HT1D-mediated IA increase requires B-Raf-dependent p38 MAPK signaling.
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5-HT1D decreases membrane excitability of TG neurons.